Scott Petersen gave a talk at Mozilla where he showed off "C-compiled versions of Lua, Ruby, Perl, and Python all running on the web in secure Flash sandboxes". There's other goodies, including a Zelda mention, in the link above. Or see this previous post for more links on C and C++ via ActionScript 3.
I wonder what the chances are for this all to get released, given the "native byte array that maps directly to RAM" and anything else that needed to be added the player to get this to work? It certainly would change Flash development dramatically, making a lot more developers interested in the Flash ecosystem. I also think it's something that Adobe would use to bring a lot more applications onto the Web, given the company's history in C and C++ development.